1 General Introduction. - A. Biological Importance of Calcium. - B. Methods for Analysis and Tissue Concentrations of Calcium. - C. Redistribution of Calcium during Stimulation. - D. Regulation of Cell Calcium. - E. Calcium and the Regulation of Membrane Permeability. - F. Calcium Ionophores. - G. Calcium Antagonists. - H. Summary and Conclusions. - 2 Survey of Calcium Action in Stimulus-Secretion Coupling. - A. General Features of the Secretory Process. - B. Historical Development of the Concept of Stimulus-Secretion Coupling. - C. Other Neuronal Systems. - D. Histamine Release from Mast Cells. - E. Lysosomal Enzyme Release from Neutrophils. - F. Blood Platelet Release Reaction. - G. Exocrine Secretion. - H. Gastric Secretion. - I. Endocrine Secretion. - J. Perspective. - 3 Nature of the Role of Calcium in Secretion. - A. Membrane Fusion. - B. Energy Metabolism and Secretion. - C. Microtubule Microfilament System. - D. Secretion as a Contractile Event. - E. Calcium-Binding Proteins. - F. Phospholipid Metabolism. - 4 Interaction of Calcium with Other Putative Mediators. - A. Analysis of the Role of Cyclic AMP in Secretion. - B. Analysis of the Role of Cyclic GMP in Secretion. - C. Analysis of the Role of Prostaglandins in Secretion. - Epilogue. - References. Language: English